SuicidDentistV1, Main, Exploration, bibRecord, 000371

Clinical and pathological aspects of epithelial hyperplasia.

Identifieur interne : 000371 ( Main/Exploration ); précédent : 000370; suivant : 000372

Clinical and pathological aspects of epithelial hyperplasia.

Auteurs : Mihaela Gîrtan ; Florica St Niceanu ; Sabina Zurac ; Elisabeta Laba ; Norina Forna

Source :

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi [ 0048-7848 ]

RBID : pubmed:20201276

Descripteurs français

KwdFr :
- Adulte (MeSH), Antigène KI-67 (métabolisme), Biopsie (MeSH), Diabète de type 1 (anatomopathologie), Diabète de type 1 (génétique), Diabète de type 1 (métabolisme), Gènes p53 (génétique), Humains (MeSH), Hyperplasie (anatomopathologie), Immunohistochimie (MeSH), Marqueurs biologiques (métabolisme), Muqueuse de la bouche (anatomopathologie), Muqueuse de la bouche (métabolisme), Mâle (MeSH).
MESH :
- anatomopathologie : Diabète de type 1, Hyperplasie, Muqueuse de la bouche.
- génétique : Diabète de type 1, Gènes p53.
- métabolisme : Antigène KI-67, Diabète de type 1, Marqueurs biologiques, Muqueuse de la bouche.
- Adulte, Biopsie, Humains, Immunohistochimie, Mâle.

English descriptors

KwdEn :
- Adult (MeSH), Biomarkers (metabolism), Biopsy (MeSH), Diabetes Mellitus, Type 1 (genetics), Diabetes Mellitus, Type 1 (metabolism), Diabetes Mellitus, Type 1 (pathology), Genes, p53 (genetics), Humans (MeSH), Hyperplasia (pathology), Immunohistochemistry (MeSH), Ki-67 Antigen (metabolism), Male (MeSH), Mouth Mucosa (metabolism), Mouth Mucosa (pathology).
MESH :
- chemical , metabolism : Biomarkers, Ki-67 Antigen.
- genetics : Diabetes Mellitus, Type 1, Genes, p53.
- metabolism : Diabetes Mellitus, Type 1, Mouth Mucosa.
- pathology : Diabetes Mellitus, Type 1, Hyperplasia, Mouth Mucosa.
- Adult, Biopsy, Humans, Immunohistochemistry, Male.

Abstract

In many cases, the oral health status indicates the general status of the body. 90% of the disorders of the body also manifest at the level of the oral cavity, which means that the dentist can draw the attention of a certain health problem. Diabetes mellitus is associated with a high prevalence of the lesions of the oral mucous, especially lichen planus, recurrent aphthous stomatitis or oral candidiasis. We present here a case of diabetes mellitus with hyperplasic lesion at the level of the inferior vestibule, extended to the right jugal mucosa. The lesion appeared pursuant to the application of removable prosthetics. The biopsy specimen was examined using normal and special staining (HE Hematoxiline - eosine, Van Gieson VG) and immunohistochemistry (IHC). In the HE stain, an epithelial hyperplasia was noticed as a result of the proliferation of the basal cells, associated with hyperkeratosis (parakeratosis or orthokeratosis). A moderated inflammatory limphoplasmocitary infiltrate, composed by lymphocytes and plasma cells, was present within the hyperplasic chorion. The immunohistochemical reactions revealed Ki-67 positive nuclei in the basal and suprabasal strata (indicating an increased proliferating activity); rare p53 positive nuclei in the basal stratum (indicating a suppressive action on the cell proliferation); CD3/CD8 positive cells in the inflammatory infiltrate (indicating an important number of T suppressor lymphocytes in the inflammatory infiltrate). In conclusion, diabetes mellitus is a disease which frequently determines major modifications at the level of the oral cavity. Interdisciplinary collaboration between the pathologist and the dentist is necessary for adequate diagnosis and successful treatment.

PubMed: 20201276

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Biomarkers (metabolism)</term>
<term>Biopsy (MeSH)</term>
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<term>Diabetes Mellitus, Type 1 (metabolism)</term>
<term>Diabetes Mellitus, Type 1 (pathology)</term>
<term>Genes, p53 (genetics)</term>
<term>Humans (MeSH)</term>
<term>Hyperplasia (pathology)</term>
<term>Immunohistochemistry (MeSH)</term>
<term>Ki-67 Antigen (metabolism)</term>
<term>Male (MeSH)</term>
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<term>Mouth Mucosa (pathology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Antigène KI-67 (métabolisme)</term>
<term>Biopsie (MeSH)</term>
<term>Diabète de type 1 (anatomopathologie)</term>
<term>Diabète de type 1 (génétique)</term>
<term>Diabète de type 1 (métabolisme)</term>
<term>Gènes p53 (génétique)</term>
<term>Humains (MeSH)</term>
<term>Hyperplasie (anatomopathologie)</term>
<term>Immunohistochimie (MeSH)</term>
<term>Marqueurs biologiques (métabolisme)</term>
<term>Muqueuse de la bouche (anatomopathologie)</term>
<term>Muqueuse de la bouche (métabolisme)</term>
<term>Mâle (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term>
<term>Ki-67 Antigen</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Diabète de type 1</term>
<term>Hyperplasie</term>
<term>Muqueuse de la bouche</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Diabetes Mellitus, Type 1</term>
<term>Genes, p53</term>
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<term>Gènes p53</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Diabetes Mellitus, Type 1</term>
<term>Mouth Mucosa</term>
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<term>Marqueurs biologiques</term>
<term>Muqueuse de la bouche</term>
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<term>Hyperplasia</term>
<term>Mouth Mucosa</term>
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<term>Biopsy</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Male</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Biopsie</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en">In many cases, the oral health status indicates the general status of the body. 90% of the disorders of the body also manifest at the level of the oral cavity, which means that the dentist can draw the attention of a certain health problem. Diabetes mellitus is associated with a high prevalence of the lesions of the oral mucous, especially lichen planus, recurrent aphthous stomatitis or oral candidiasis. We present here a case of diabetes mellitus with hyperplasic lesion at the level of the inferior vestibule, extended to the right jugal mucosa. The lesion appeared pursuant to the application of removable prosthetics. The biopsy specimen was examined using normal and special staining (HE Hematoxiline - eosine, Van Gieson VG) and immunohistochemistry (IHC). In the HE stain, an epithelial hyperplasia was noticed as a result of the proliferation of the basal cells, associated with hyperkeratosis (parakeratosis or orthokeratosis). A moderated inflammatory limphoplasmocitary infiltrate, composed by lymphocytes and plasma cells, was present within the hyperplasic chorion. The immunohistochemical reactions revealed Ki-67 positive nuclei in the basal and suprabasal strata (indicating an increased proliferating activity); rare p53 positive nuclei in the basal stratum (indicating a suppressive action on the cell proliferation); CD3/CD8 positive cells in the inflammatory infiltrate (indicating an important number of T suppressor lymphocytes in the inflammatory infiltrate). In conclusion, diabetes mellitus is a disease which frequently determines major modifications at the level of the oral cavity. Interdisciplinary collaboration between the pathologist and the dentist is necessary for adequate diagnosis and successful treatment.</div>
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<Abstract><AbstractText>In many cases, the oral health status indicates the general status of the body. 90% of the disorders of the body also manifest at the level of the oral cavity, which means that the dentist can draw the attention of a certain health problem. Diabetes mellitus is associated with a high prevalence of the lesions of the oral mucous, especially lichen planus, recurrent aphthous stomatitis or oral candidiasis. We present here a case of diabetes mellitus with hyperplasic lesion at the level of the inferior vestibule, extended to the right jugal mucosa. The lesion appeared pursuant to the application of removable prosthetics. The biopsy specimen was examined using normal and special staining (HE Hematoxiline - eosine, Van Gieson VG) and immunohistochemistry (IHC). In the HE stain, an epithelial hyperplasia was noticed as a result of the proliferation of the basal cells, associated with hyperkeratosis (parakeratosis or orthokeratosis). A moderated inflammatory limphoplasmocitary infiltrate, composed by lymphocytes and plasma cells, was present within the hyperplasic chorion. The immunohistochemical reactions revealed Ki-67 positive nuclei in the basal and suprabasal strata (indicating an increased proliferating activity); rare p53 positive nuclei in the basal stratum (indicating a suppressive action on the cell proliferation); CD3/CD8 positive cells in the inflammatory infiltrate (indicating an important number of T suppressor lymphocytes in the inflammatory infiltrate). In conclusion, diabetes mellitus is a disease which frequently determines major modifications at the level of the oral cavity. Interdisciplinary collaboration between the pathologist and the dentist is necessary for adequate diagnosis and successful treatment.</AbstractText>
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<name sortKey="Laba, Elisabeta" sort="Laba, Elisabeta" uniqKey="Laba E" first="Elisabeta" last="Laba">Elisabeta Laba</name>
<name sortKey="St Niceanu, Florica" sort="St Niceanu, Florica" uniqKey="St Niceanu F" first="Florica" last="St Niceanu">Florica St Niceanu</name>
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	Serveur d'exploration sur le suicide chez les dentistes
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Serveur d'exploration sur le suicide chez les dentistes

Clinical and pathological aspects of epithelial hyperplasia.

Clinical and pathological aspects of epithelial hyperplasia.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki